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Vulvovaginal and Labia Rejuvenation Treatment

Relieve VVA Symptoms
Improve Overall Vulvar Skin Quality
Improve Sexual Experience 

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Vulvovaginal Atrophy

Vulvovaginal atrophy (VVA) and labia rejuvenation treatments address conditions causing the tissues in the vulva, vagina, and labia to become thinner, drier, and less elastic. This can lead to discomfort, pain, itching, and burning. It’s primarily caused by a decrease in estrogen levels and most common in women after menopause, but it can also occur in women who have had their ovaries removed or who are taking certain medications.

VVA premenopausal after menopause

Vulvovaginal Atrophy
Common Symptoms

Here are the common symptoms:

  • Dryness
  • Itching
  • Burning
  • Pain during sex
  • Painful urination
  • Discomfort when sitting
  • Redness and swelling of the vulva
newgyn vva ve ba menopause

Vulvovaginal Atrophy

Functional Impact:

  • Vaginal Dryness
  • Irritation
  • Dyspareunia
  • Itching
  • Tenderness / Tingling

Aesthetic Impact:

  • Vaginal Pallor
  • Reduce Vaginal Elasticity
  • Labia Minora Resorption
  • Urethral Prolapse

Relational Emotional Impact:

  • Couple Intimacy
  • Decreased libido, Pleasure and Sexual Spontaneity
  • Decreased Quality of Life with Psycho-social Stress

What Is NewGyn

NewGyn is composed of Polynucleotides-HPT® (PN-HPT®), a DNA fragment extracted from ethically bred Italian trout fish using a patented DNA extraction and purification technology developed by Mastelli, Italy.
The role of PN-HPT® is to repair aging and damaged tissue by increasing the proliferation and vitality of fibroblasts, enhancing Collagen I & II synthesis, and inducing deposition in the extracellular matrix.
In addition to PN-HPT®, NewGyn contains two other ingredients: Hyaluronic Acid, which provides hydration, and Mannitol, which protects Hyaluronic Acid (HA) and prolongs its activity over time.
Apart from treating VVA, NewGyn is also effective for labia rejuvenation, restoring its youthful appearance and feel.

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How Does It Work

At the heart of NewGyn’s efficacy is Polynucleotides-HPT® (PN-HPT®). This component, refined through Mastelli’s innovative technology, revitalises tissues showing signs of aging or damage. It does so by stimulating fibroblasts, the cells responsible for tissue regeneration, and enhancing the production of vital skin proteins, Collagen I & II. This results in improved skin elasticity and structural reinforcement. To further optimise its effects, NewGyn integrates Hyaluronic Acid, ensuring tissues remain moisturised, and Mannitol, which safeguards and extends the longevity of the hydration benefits.

NewGyn’s Triple-Action Formula​

PN-HPT® (Polynucleotides-HPT) exhibits remarkable therapeutic properties that contribute significantly to tissue regeneration and repair. It actively boosts the proliferation and vitality of fibroblasts, essential cells involved in wound healing and tissue repair. Furthermore, PN-HPT® enhances the synthesis of Collagen I & II, vital proteins for maintaining skin elasticity and strength. This not only promotes the production of these collagens but also induces their deposition in the extracellular matrix, ensuring structural integrity. As a result, PN-HPT® plays a pivotal role in repairing aging and damaged tissue, showcasing its potential in regenerative medicine.

Hyaluronic acid (HA) plays a crucial role in the vulvovaginal mucosa, ensuring hydration, firmness, and tone. However, as the aging process unfolds, there’s a decline in the production of hyaluronic acid. This reduction leads to a progressive loss of hydration, coupled with diminished firmness and tone of the tissue. Interestingly, when PN-HPT is combined with HA, even in minimal concentrations, a synergistic effect emerges. This association amplifies the benefits, offering enhanced hydration and rejuvenation to the vulvovaginal area.

Mannitol serves as a protective agent for Hyaluronic Acid (HA) in the NewGyn formulation. It shields HA from the detrimental effects of enzymatic degradation and oxidative stress, ensuring its integrity and functionality. More than just protection, Mannitol extends the activity of HA over time. This prolonged action means that HA’s beneficial effects, such as hydration and tissue rejuvenation, persist for longer durations, maximizing the overall efficacy of the NewGyn treatment.

– Guizzadi S, Uggeri J, Belletti S, Cattarini G. Hyaluronate increases polynucleotides effect on human cultured fibroblasts. Journal of Cosmetics, Dermatological Sciences and Applications 2013; 3: 124-128
– Colangelo MT, Govoni P, Belletti S, Passi A, Guizzardi S, Galli C. Polynucleotide biogel enhances tissue repair, matrix deposition and organization. Journal of biological regulators & homeostatic agents 2021; 35 (1): 355-362

Clinical Results

Reduction of VVA symptoms and noticeable labia rejuvenation after the first 2 sessions

Conclusion: This study indicates that the known benefits of polynucleotides on the skin, as well as their combined effects with hyaluronic acid, may also apply to post-menopausal vulvovaginal tissues. However, further controlled trials are needed to confirm these findings.

Palmieri IP. Biorevitalization of postmenopausal labia majora, the polynucleotide/hyaluronic acid option. Obstetrics and gynecology reports 2019; 3:1-5


VVA is a condition characterized by the thinning, drying, and inflammation of the vaginal walls due to a decrease in estrogen levels, commonly occurring after menopause.

NewGyn is an injectable treatment which introduce substances that can help restore hydration, elasticity, and health to the vaginal tissues, by promoting collagen production or retaining moisture.

Yes, NewGyn is effective not only for treating VVA but also for rejuvenating the labia, restoring its natural elasticity and appearance.

While some discomfort (depending on individual pain threshold) might be felt during the injection, local anaesthetics is used to minimise any pain.

The recommended treatment protocol involves injecting at the vulvar skin dermis and mucosal lamina propria area in 3-6 sessions (depending on severity of symptoms), spaced 2-4 weeks apart to achieve optimal results. For maintenance and to ensure continued benefits, it’s advised to have a follow-up session every 2-6 months.

As with any medical procedure, there can be side effects. Common ones might include temporary injection site marks, swelling or bruising at the injection site, which typically subside within 24 hours.

After the procedure, you can continue with most of your daily activities. However, you should refrain from sexual activity for 24-72 hours. It’s also advised to avoid using tampons, taking hot baths, or visiting saunas and swimming pools for a few days. Wear loose, breathable underwear and avoid vigorous exercises that might cause friction in the treated area. Always monitor for any signs of infection or unusual symptoms and consult your healthcare provider if needed.

Meet Dr.Ain

Dr. Ain, Malaysia’s Trainer Doctor for Injectables from Mastelli Aesthetics, Italy, shared various techniques on injecting Polynucleotides (PN-HPT) (Plinest by Mastelli Aesthetics) at the Plinest Workshop 2022.

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