Comprehensive Guide to Ozempic Semaglutide. Discover How It Can Aid Diabetes Control.
Ozempic (Semaglutide) is a once-weekly injectable prescription medicine that may improve blood sugar (glucose) levels in adults with type 2 diabetes. It also contributes to weight loss and reduces the risk of major adverse cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes with known heart disease.
What is Ozempic
Ozempic is a brand name for the drug semaglutide. It is a glucagon-like peptide 1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is also used to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus and established cardiovascular disease.
In Malaysia, the product registration for Ozempic (label on the box): MAL20026057AZ and MAL20026058AZ.
What is Semaglutide
Semaglutide is the active ingredient in Ozempic. It is a human glucagon-like peptide-1 (GLP-1) receptor agonist1 that has a strong affinity for the GLP-1 receptor, a receptor that helps regulate glucose metabolism.
1. A GLP-1 receptor agonist is a special key that helps to activate the receptors in our body, producing similar effects to the GLP-1 hormone itself.
How does it work
Semaglutide works by mimicking the function of the GLP-1 hormone. This hormone is released into the bloodstream from the intestines after a meal, and it stimulates the secretion of insulin while suppressing the release of glucagon, both of which help to regulate blood sugar levels.
The stomach is responsible for breaking down food and emptying it into the small intestine. Semaglutide affects GLP-1 receptors in the stomach, slowing down gastric emptying. This means that food stays in the stomach for a longer time, leading to a feeling of fullness and reduced appetite. Slower gastric emptying also helps to prevent rapid rises in blood sugar levels after meals.
The pancreas produces insulin and glucagon, two hormones involved in blood sugar regulation. Semaglutide stimulates GLP-1 receptors in the pancreas, promoting the production of insulin and suppressing the release of glucagon. This dual effect helps to lower blood sugar levels and improve insulin sensitivity, which is particularly beneficial for individuals with type 2 diabetes who may have insulin resistance and reduced insulin production.
The liver plays a crucial role in regulating glucose production. Semaglutide’s impact on GLP-1 receptors in the liver helps reduce excessive glucose production, leading to better blood sugar control. By moderating glucose production, semaglutide contributes to maintaining stable blood sugar levels.
Who is a good candidate
Ozempic (Semaglutide) is suitable for adults with type 2 diabetes who are inadequately controlled on diet and exercise alone or in combination with one or more other antidiabetic medicines. It is particularly beneficial for those who also have established cardiovascular disease, as it can help reduce the risk of adverse cardiovascular events.
Like all medications, Ozempic (Semaglutide) can cause side effects. The most common side effects include nausea, vomiting, diarrhea, abdominal pain, and decreased appetite. However, not everyone will experience these and they are often temporary, improving over time.
If you experience side effects, it’s important to discuss them with your doctor. They can provide advice on how to manage these side effects, which may include adjusting the dose of Ozempic or suggesting other ways to alleviate symptoms.
Ozempic (Semaglutide) should not be used in patients with a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2. It is also not recommended for patients with a history of diabetic retinopathy.
Clinical studies have shown that treatment with Ozempic (Semaglutide) results in a significant reduction in HbA1c (a measure of blood sugar control) compared to placebo.
This study has found that semaglutide resulted in a significantly greater reduction in body weight than placebo. The mean change in body weight from baseline to week 68 was -15% in the semaglutide group and -2.4% in the placebo group.
Ozempic (semaglutide) is primarily prescribed for the treatment of type 2 diabetes. It is designed to improve blood sugar (glucose) control in adults with this condition. While weight loss can be a side effect of taking Ozempic, it’s important to note that it is not approved as a weight-loss medication for individuals without type 2 diabetes.
Ozempic is not a substitute for a healthy diet and regular exercise. These lifestyle modifications are crucial components of managing type 2 diabetes. Ozempic is most effective when used in combination with a balanced diet and regular physical activity.
A common piece of feedback we often receive from our patients is that Ozempic makes adhering to a balanced diet and regular physical activity easier.
The cost of Ozempic can vary depending on your dosage. Generally it can cost between RM800 to RM1,000 per month of usage.
It’s important to discuss your full medical history with your doctor before starting Ozempic.
Ozempic (semaglutide) involves a once-weekly subcutaneous injection. It can be taken at any time of the day, with or without meals. However, it should be taken on the same day each week.
Ozempic starts working soon after the first dose, but it may take several weeks to see the full effects on your blood sugar control.
To achieve the best results with Ozempic (Semaglutide), it’s important to use it as directed by your doctor. This includes maintaining a healthy diet, engaging in regular exercise, and performing regular monitoring of your blood sugar levels. Moreover, it’s crucial to have ongoing medical supervision throughout your treatment journey. Your doctor can assist with any necessary adjustments to your treatment plan and monitor for potential side effects. This personalised attention can significantly enhance the safety and effectiveness of your treatment with Ozempic.
Since 2015, Dr. Ain has established herself as a prominent Key Opinion Leader in the field of body contouring and weight management. As the driving force behind Alainn Clinic, she has been at the forefront of adopting cutting-edge treatments. Dr. Ain’s active involvement in clinical studies, along with her extensive knowledge and expertise, ensures that patients at Alainn Clinic receive optimal and significant outcomes.
Stay Alert (16/6/23): Fake Ozempic reported by Novo Nordisk. Learn More.