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Trulicity Dulaglutide

Learn How Trulicity Dulaglutide Can Aid Diabetes Control And Weight Loss.

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Trulicity (Dulaglutide) is a once-weekly injectable prescription medicine designed to improve blood sugar (glucose) levels in adults with type 2 diabetes. Additionally, it aids in weight management and has shown potential in reducing cardiovascular risks in certain patient groups.

What is Trulicity

Trulicity, produced by Eli Lilly and Company, is a brand name for the drug dulaglutide. It is a glucagon-like peptide 1 (GLP-1) receptor agonist recommended as an adjunct to diet and exercise to enhance glycemic control in adults with type 2 diabetes mellitus.
 In Malaysia, Trulicity is available in two dosage strengths, 1.5mg and 0.75mg, catering to the varied needs of patients.

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What is Dulaglutide

Dulaglutide is the active ingredient in Trulicity. It is a human glucagon-like peptide-1 (GLP-1) receptor agonist that binds to the GLP-1 receptor, playing a pivotal role in glucose metabolism.

Molecular Structure Dulaglutide
1. A GLP-1 receptor agonist is a special key that helps to activate the receptors in our body, producing similar effects to the GLP-1 hormone itself.

How does it work

Dulaglutide functions by imitating the GLP-1 hormone, which is secreted into the bloodstream post-meal. This hormone boosts insulin secretion while inhibiting glucagon release, both crucial for blood sugar regulation. By affecting GLP-1 receptors, dulaglutide slows gastric emptying, leading to prolonged satiety and controlled blood sugar spikes post meals.

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Who is a good candidate

Trulicity (Dulaglutide) is ideal for adults with type 2 diabetes whose condition isn’t adequately managed with diet and exercise alone or with other antidiabetic medications. It’s especially beneficial for those with an increased risk of cardiovascular events.

Side effects

Like all medications, Trulicity (Dulaglutide) can have side effects. Common ones include nausea, vomiting, diarrhea, abdominal discomfort, and reduced appetite. These effects are generally temporary and may diminish over time. It’s crucial to consult with your doctor about any experienced side effects. They are equipped to offer advice, which could involve adjusting the dosage or recommending strategies to ease the symptoms.
Tips to manage GLP-1 receptor agonist-based medications. Learn More.


Glucose Level: Trulicity (Dulaglutide) has been proven effective in clinical trials for significantly reducing HbA1c levels, a key marker for blood sugar control. According to a post hoc analysis published, patients treated with Trulicity experienced a notable reduction in HbA1c levels compared to those on a placebo. The study reported a least-squares mean difference of -0.61% (P < 0.001) in HbA1c levels over 72 months of treatment, underscoring Trulicity’s efficacy in long-term blood sugar management.

Weight Management: Studies have demonstrated that dulaglutide can lead to notable weight reduction, further supporting its dual role in diabetes management. In a clinical trial (NCT03495102), participants with type 2 diabetes who were treated with dulaglutide experienced a significant reduction in HbA1c levels and body weight from baseline at week 36, showcasing the medication’s efficacy in both blood sugar control and weight management


Trulicity (Dulaglutide) should not be administered to patients with a history of medullary thyroid carcinoma or those with Multiple Endocrine Neoplasia syndrome type 2. It’s also not advised for patients with severe gastrointestinal diseases.

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Sustainable results

To achieve the best results with Trulicity (Dulaglutide), it’s IMPORTANT to use it as directed by your doctor. This includes maintaining a healthy diet (easy guide), engaging in regular exercise, and performing regular monitoring of your blood sugar levels.
Moreover, it’s crucial to have ongoing medical supervision throughout your treatment journey. Your doctor can assist with any necessary adjustments to your treatment plan and monitor for potential side effects. This personalised attention can significantly enhance the safety and effectiveness of your treatment with Trucility.

Trulicity In Malaysia

Trulicity (Dulaglutide), is an approved medication by the National Pharmaceutical Regulatory Agency (NPRA) in Malaysia for use as a prescription medicine. Patients looking to use Trulicity must first undergo an evaluation or consultation with a doctor to determine if it’s suitable for their specific condition. The estimated monthly cost for Trulicity in Malaysia is around RM800.


Trulicity (dulaglutide) is primarily prescribed for the treatment of type 2 diabetes. While weight loss can be a side effect of taking Trulicity, it’s important to note that it is not approved as a weight-loss medication for individuals without type 2 diabetes.
However, there are cases of GLP-1 receptor agonists, such as dulaglutide, being used as off-label¹ treatments for weight loss. It’s essential to understand that such usage is unique and determined on a case-by-case basis, underscoring the importance of trained professional medical consultation.

¹Off-label use refers to the prescription of a medication for a condition, age group, dosage, or form that has not been approved by regulatory agencies.

No, Trulicity is not a substitute for a balanced diet and regular exercise. These lifestyle modifications are essential components of managing type 2 diabetes. Trulicity is most effective when combined with a healthy lifestyle.

It’s essential to discuss your full medical history with your doctor before starting Trulicity. Some health conditions may affect how Trulicity works or increase the risk of side effects.

Trulicity (dulaglutide) involves a once-weekly subcutaneous injection. It can be taken at any time of the day, with or without meals. However, it should be taken on the same day each week.

Trulicity starts working soon after the first dose, but it might take several weeks to observe the full effects on blood sugar control.

Both Trulicity (Dulaglutide) and Ozempic (Semaglutide) are GLP-1 receptor agonists used for type 2 diabetes treatment. They mimic the GLP-1 hormone, enhancing insulin secretion and suppressing glucagon release. However, they have distinct molecular structures. Dulaglutide is a fusion protein combining GLP-1 with a human immune protein component, while Semaglutide is modified with a fatty chain to bind with blood proteins. Both are injectable and administered once weekly, but individual results and side effects may vary.

Managing Weight Without Type 2 Diabetes

For individuals who are overweight or obese but have not been diagnosed with type 2 diabetes, managing weight effectively is still a paramount concern for overall health and well-being. There are FDA-approved medications available that can aid in weight management for those without diabetes.

One option to consider is Saxenda (liraglutide), a medication that can regulate appetite and lead to reduced food intake. Another alternative is Contrave (naltrexone/bupropion), which combines the actions of two different medications to influence the brain’s behavior towards food and appetite.

Meet Dr.Ain..​

Dr Ain Obesity Colloq Speaker 2

Since 2015, Dr. Ain has established herself as a prominent Key Opinion Leader in the field of body contouring and weight management. As the driving force behind Alainn Clinic, she has been at the forefront of adopting cutting-edge treatments. Dr. Ain’s active involvement in clinical studies, along with her extensive knowledge and expertise, ensures that patients at Alainn Clinic receive optimal and significant outcomes.